Customizable private tour with flexible departure dates. Solo travelers are welcome—contact us for availability and a personalized quote.
2-Day Ayahuasca Retreat – Overview of the Healing Journey
This 2-day Ayahuasca retreat in Cusco is a carefully guided experience created for those seeking deeper healing, clarity, and spiritual connection. With two traditional ceremonies and dedicated time for integration, this retreat offers a more complete and immersive journey, honoring Ayahuasca as a sacred medicine and allowing the process to unfold without rushing.
Enter a premium 2-day Ayahuasca retreat in Cusco, created for those seeking profound healing, spiritual clarity, and a deeper connection with ancestral Amazonian wisdom. This immersive experience allows more time for preparation, ceremony, reflection, and integration, offering a more complete and transformative journey.
This retreat is ideal for participants who feel called to go beyond a single ceremony and truly surrender to the healing process in a safe, respectful, and authentic environment.
Ayahuasca has for a long time been used as a spiritual as well as a healing medicine by the indigenous peoples of the Amazon. The teachings of Ayahuasca can lead you to enlightenment, healing and also self realization.
Ayahuasca is a holy drink made using Ayahuasca vine and Chakruna leaves; these plants are greatly honored by Amazonian and Andean peoples. This powerful plant medicine is known as ‘the grandmother spirit’ and has been used both for healing and for achieving spiritual transformation, assisting people to reach a higher level of consciousness and to have a better comprehension of the spiritual and natural world.
The Unique Power of a Cusco Ayahuasca Retreat
In the heart of the Andes, experience ayahuasca. A Cusco retreat has a different energy, one that is not jungle energy. You are surrounded by magnificent mountain, and ancient Inca power spots, and the profound wisdom of the Andes. This high-altitude environment is great for introspection and spiritual awakening.
Unhealthy Habits and Patterns
Overcoming addiction and other unhealthy habits is difficult. Therefore, the sacred medicine of ayahuasca is used for healing and detoxification. The goal is for the person to free themselves from all the ties that bind them to that pattern or addiction, while also allowing themselves to forgive and release all the harm these habits have caused.
Anxiety and Fear
As with other ailments such as depression, the sacred medicine of Ayahuasca can help with anxiety by directly addressing the root of the problem and helping the person heal and release the fears that cause it.
Exhaustion
With so much work, worries, and growing problems we face every day, it’s no surprise that many of us suffer from exhaustion. Ayahuasca offers us the opportunity to start fresh, with all our worries and difficulties. Ultimately, it will be like a reboot and will help you feel like you’re starting over with renewed energy.
Social Conditioning
Many of the decisions we make in life are conditioned by our family, friends, or society. Sometimes, to such an extent that we cease to be happy with ourselves. In this case, the benefits of Ayahuasca medicine are applied by helping people find themselves.
Post-Traumatic Stress
Ayahuasca medicine is one of the most sought-after treatments. Why? Numerous surveys highlight the benefits of this therapy, which can help overcome trauma and release the person from the situation that caused it.
Extra details
- Age Limit: Participants must be at least 18 years old to join the ceremony. There is no strict maximum age, but older participants should be in good physical and mental health. A brief health screening is required to ensure safety and readiness for the experience.
- Open Heart and Mind: The Ayahuasca ceremony is a sacred spiritual practice that requires diet. We invite you to come with love, gratitude, and an openness to connect deeply with this Master Plant.
- Personal Intention: Before the ceremony, reflect on your personal intentions
- Comfortable Clothing: We recommend wearing comfortable clothes suitable for sitting outdoors and being in nature. Layering is ideal, as mountain weather can change quickly.
- Respect for Tradition: Please approach the ceremony with respect for the Andean traditions and the guidance of the Master who will be leading the ceremony.
- Physical Condition: Please be honest about your health. The ceremony requires that you share any physical or mental health conditions with the Master beforehand. If you take any medications or substances, it’s important to let us know in advance. This helps ensure your safety and allows us to support your experience with care and respect. In specific cases a participation in the ceremony can be denied.
Why Choose a 2-Day Ayahuasca Retreat?
A two-day Ayahuasca retreat provides the space necessary for deeper inner work. While one ceremony can open the door, a second day allows the medicine to work at a more subtle and profound level.
With more time, participants often experience:
- Deeper emotional release
- Greater mental clarity
- Stronger spiritual insights
- A smoother and more meaningful integratio
This premium retreat is designed for those who want to honor the process without rushing it.
Who Is This Retreat For?
This 2-day Ayahuasca Ceremony in Cusco is ideal for:
- Participants seeking deep emotional or spiritual healing
- Those who want a more complete Ayahuasca experience
- Individuals ready for introspection and personal transformation
- People who value a safe, structured, and respectful environment
While suitable for first-time participants, this retreat is especially recommended for those who feel prepared for a deeper journey.
Prices & Inclusions
Our passion for spiritual retreats is rivaled only by the impulse to share it with others. By taking care of all the details and setting you up for new adventures. Meanwhile, we deliver moments of joy, both humble and grandiose.
Costs (per person)
How to Book
- Send Your Inquiry Share your preferred dates, number of participants, and accommodation details.
Solo travelers or guests with questions are welcome to contact us before booking. - Confirm Availability We will coordinate availability, ceremony logistics, and the best schedule for your experience.
- Reservation Deposit A deposit is required to secure and confirm your reservation.
- Booking Confirmation Once your reservation is confirmed, we will send all final details including pick-up time, recommendations, and important information for your ceremony.
What Is Included in the 2-Day Ayahuasca
Not Included
Ayahuasca Retreat Itinerary
Ceremony & Introduction
These ceremonies take place in the evening. Depending on your location, we will pick you up around 4:00 PM and bring you to Chinchero, where our center and the ceremony are held. You will have the option to either spend the night in Chinchero after the ceremony or return to your accommodation in Cusco or the Sacred Valley the same evening. Upon arrival, you will receive an introduction to the medicine and a talk about working with Master Plants. The ceremony itself typically lasts between 3 to 4 hours. During the ceremony, our Ayahuasca Master will guide and support your process with various rituals and sacred icaros (healing songs).
The amount of medicine given to each participant is carefully determined based on their energy level and mental strength – it is not a standard dose for everyone, but rather tailored to individual needs. After the ceremony, we will transport you back to your location unless you choose to stay overnight.

Reintegration & Return
If you decide to stay in Chinchero, the following morning you will participate in a reintegration circle to help you process and integrate your experience. Afterwards, our transportation will return you to your hotel in Cusco.
This day is focused on understanding and carrying forward the insights from your Ayahuasca journey. The reintegration circle provides a supportive space for sharing and reflection.

Why Choose 2 Days Over 1? — The Case for Going Deeper
This is the most common question we receive from travelers considering this retreat. Here is an honest answer:
A single Ayahuasca ceremony can be profoundly meaningful. Many people receive exactly what they need in one night. But Ayahuasca is not linear. The medicine works in layers — and sometimes the first ceremony is primarily a process of opening, of releasing surface defenses, of establishing trust with the plant and the space.
The second ceremony, with that opening already complete, tends to work differently: more specific, more direct, more intimate. The medicine has already introduced itself. Now it can do deeper work.
What the second day and ceremony makes possible:
- Integration between ceremonies. The morning after the first ceremony is one of the most valuable moments of the entire retreat. With your guide present, you have time to sit with what emerged, ask questions, and understand what the medicine showed you — before going in again.
- Layered healing. What the first ceremony surfaces, the second often resolves. The two-ceremony arc mirrors the natural structure of deep therapeutic work: opening, processing, integration.
- Reduced pressure. Knowing there is a second night removes the unconscious pressure to receive everything in a single session. This relaxation of expectation often allows the first ceremony to be more open and receptive.
- Overnight immersion in Chinchero. Rather than returning to the city after the ceremony, you stay overnight in the Sacred Valley — waking with the mountains, eating a light breakfast in nature, and beginning the second day grounded in the landscape that held your first night.
If your time in Cusco permits it, the 2-day retreat is the format we recommend without hesitation.
Traveling with limited time? See our 1-Day Ayahuasca Retreat in Cusco.
What’s Included in Your 2-Day Ayahuasca Retreat
- Private round-trip transportation from your hotel in Cusco to Chinchero
- Two traditional Ayahuasca ceremonies led by an experienced Andean Master
- Preparatory Coca Leaf Reading on Day 1
- Overnight accommodation in Chinchero (Sacred Valley)
- Light meals and herbal teas on both days (breakfast and light dinner)
- Bilingual guide present throughout (English, Spanish, Quechua)
- Integration circle on Day 2 morning
- All ceremonial materials (icaros, flowers, incense, sacred objects)
- Post-retreat integration support and guidance
Not included: full meals beyond what is listed above, travel insurance, personal medications, gratuity for the Master and guide (warmly appreciated).
Safety — Who Can Participate in the 2-Day Ayahuasca Retreat
Your safety is the non-negotiable foundation of every ceremony we hold. Before confirming your booking, a health screening is required. There are genuine contraindications to Ayahuasca that must be honored.
You can participate if:
- You are 18 years of age or older
- You are in generally good physical and mental health
- You are not currently taking SSRIs, MAOIs, lithium, or antipsychotics
- You have no personal or family history of schizophrenia, bipolar I, or psychosis
- You are willing to follow the preparatory diet
- You are willing to disclose your full health history honestly
You should not participate if:
- You have a serious heart condition or uncontrolled hypertension
- You have a personal or family history of schizophrenia or psychosis
- You are currently pregnant or breastfeeding
- You are on psychiatric medications (discuss with your doctor and inform us in advance)
- You have used recreational drugs in the 7 days prior to the ceremony
- You are in acute mental health crisis without professional support
If you are uncertain about your situation, contact us before booking. We will advise you honestly — including recommending you do not attend if we believe the circumstances are not safe for you at this time.
The Cusco Ayahuasca Retreat Difference — Why This Location Matters
The majority of Ayahuasca retreats operate in the Amazon jungle of Peru — Iquitos, Pucallpa, Tarapoto. At PumAdventures, our ceremonies take place in Chinchero, Sacred Valley, at 3,762 meters above sea level in the Andes. This is not a compromise — it is a deliberate choice that creates a distinctly different experience.
The energy of the Andes is different from the jungle. Where the Amazon environment tends to be dense, humid, and inward-facing, the Andean landscape is open, vast, and sky-oriented. Working with Ayahuasca here tends to produce a quality of expansiveness and clarity alongside the inner depth that the medicine always brings.
The Apus are active participants. In Andean cosmology, the mountain peaks surrounding Chinchero — including Salkantay, Ausangate, and the range above the Sacred Valley — are living spiritual beings of enormous power and benevolence. Their presence during ceremony is real and felt. Many participants describe the mountains as a holding presence throughout the night.
The altitude creates a natural threshold. At nearly 4,000 meters, the body is already in an altered relationship with oxygen, energy, and perception. This physiological shift can amplify the medicine’s capacity for depth and openness.
The lineage is Andean and intact. Our Masters come from Chinchero families who have worked with these plant medicines for generations — in relationship with this land, these mountains, and this particular spiritual tradition. The ceremony is not imported or reconstructed. It is native to this place.
What Ayahuasca Can Address — Areas of Healing
Ayahuasca does not treat diseases in a clinical sense. It is a sacred traditional practice, not a medical protocol. That said, participants across thousands of ceremonies have reported meaningful shifts in conditions that conventional approaches often struggle to address:
Trauma and Post-Traumatic Stress
Ayahuasca has an unusual capacity to bring traumatic memories into conscious experience in a way that feels survivable — held by the medicine, the ceremony, and the Master. Many participants describe a process of revisiting difficult events from a new vantage point, one that allows release, reframing, or forgiveness where previously there was only pain. The growing body of clinical research on psychedelic-assisted therapy reflects what indigenous traditions have long understood: that some wounds are healed not by talking about them, but by meeting them directly in an altered and supported state of consciousness.
Anxiety, Fear, and Depression
Rather than managing symptoms, Ayahuasca tends to work toward the root — the underlying fear, the original wound, the moment a story about oneself was formed and calcified. The experience is not always comfortable, but participants frequently report a lasting reduction in anxiety and a renewed sense of possibility and meaning after the retreat.
Grief and Loss
Unprocessed grief — from death, separation, failed relationships, or lost versions of oneself — responds particularly well to plant medicine work. The medicine does not rush grief away. It creates conditions in which grief can be fully felt, honored, and released.
Addiction and Compulsive Patterns
The addictive loop is, at its core, a search for relief from pain. Ayahuasca often works by surfacing and healing the pain that is being avoided — making the compulsion lose its grip, not through willpower, but through genuine resolution of what was driving it. This is not a guarantee, and integration support is essential for lasting change.
Spiritual Disconnection and Loss of Meaning
Many people arrive at Ayahuasca not in acute crisis but in a quieter kind of pain — a sense that life has become mechanical, that purpose is unclear, that the depth they once felt is no longer accessible. The medicine tends to address this directly, restoring a felt sense of connection — to oneself, to others, to the living world.
Note: Ayahuasca is a sacred traditional practice. It is not a substitute for medical or psychological treatment. We always recommend working in parallel with a qualified mental health professional, particularly for trauma or clinical diagnoses.
The Preparatory Diet — Dieta Before Your Ayahuasca Retreat
In the Shipibo tradition, the dieta is not simply a set of food restrictions. It is a process of energetic refinement — preparing the body and mind to receive the medicine with maximum openness and minimum interference.
One week before the retreat, avoid:
- Pharmaceutical drugs (especially SSRIs, MAOIs, stimulants, antidepressants)
- Alcohol and all recreational substances
- Pork and red meat
- Fermented foods (pickles, vinegar, aged cheeses, soy sauce)
- Caffeine and chocolate
- Carbonated drinks and refined sugar
- Heavily spiced or processed foods
Three days before, additionally:
- Avoid sexual activity
- Minimize screen time and social stimulation
- Spend time in quiet reflection, nature, and journaling
Day of the ceremony:
Fast from the morning — do not eat for at least 6 hours before the ceremony begins
Drink only water or light herbal tea
Arrive rested and calm
Why this matters: Many of the foods on this list contain tyramine or other compounds that interact directly with the MAO-inhibiting alkaloids in Ayahuasca. Some interactions are dangerous. Others simply reduce the clarity of the experience. The dieta protects both your safety and the quality of what you receive.
Continue Your Healing Journey in Cusco
Many participants who complete this retreat choose to extend their time with us, adding complementary experiences before or after the ceremonies:
- 1-Day Ayahuasca Retreat in Cusco — ideal if your schedule only allows one night
- San Pedro (Wachuma) Ceremony — the daytime Andean medicine that complements Ayahuasca with heart-opening and solar energy
- Coca Leaf Reading — clarify your intention before the retreat or integrate afterward
- Offering to Pachamama – Despacho — a powerful act of gratitude and reciprocity to close your time with the sacred medicines
- Essence of Cusco – 5 Day Spiritual Retreat — combines Ayahuasca, San Pedro, Despacho, and Coca Leaf Reading into a single guided journey
- Healing Peru – 10 Day Retreat — for those ready for a complete immersion across multiple traditions and landscapes
FAQs
This is a great query that gets to the core of our work. Though the Amazon is Ayahuasca’s holy birthplace, experiencing it in Cusco provides a strikingly different but equally strong energy. The Andes’ big mountain spirits, the Apus, welcome you here. This establishes a grounding, solid, and protective energy for your travels. Incorporating ceremonies like coca leaf readings or Pachamama (Mother Earth) offerings, our ayahuasca ritual in Cusco sometimes combines traditional Amazonian practices with Andean knowledge.
This one-of-a-kind combination offers a vessel of great spiritual power, so facilitating the integration of Ayahuasca’s celestial visions with the profound, fundamental energy of the earth. Many think the more crisp, high-altitude energy of Cusco aids in negotiating the depths of the drug with more awareness and focus.
The definition of any real retreat and our top concern is your safety. To guarantee a genuinely secure and transforming ayahuasca trip in Peru, particularly in Cusco, you must search for certain important markers. Experienced Maestros or Maestras, frequently from Shipibo or Q’ero ancestry, who have devoted their lives to a demanding route of instruction and dietas, lead first authentic centers. Second, ceremonies’ group sizes have to be small and cozy.
This helps the shaman to give individual attention and keep a powerful, protective energetic containment for all. At last, a really responsible center will provide devoted integration assistance following your events and conduct a thorough medical screening procedure. Never select a retreat that makes great claims or stresses you; the actual path is one of modesty, respect, and deep concern for every participant.
Stepping into a sacred, eternal realm is like entering an ayahuasca ceremony in Cusco. Usually conducted at night in a darkened room or maloka, the ritual aims to assist you concentrate inward. Prayer and the cleansing smoke of mapacho (sacred tobacco) will mark the beginning of our Maestro’s opening of the area. You will drink the medication, which tastes earthy and strong after setting your goal. The Maestro starts to hum the icaros—sacred melodies that are the language of the plant spirits—as the medicine kicks in.
These compositions steer the voyage, remove bad energies, and help one to negotiate the visionary worlds. Deep insights, emotional discharge, physical expulsion (vomiting, regarded as a strong cleanse), and a great feeling of oneness with the cosmos could come on. To make sure you feel held and secure throughout the whole process, our facilitators are always on hand to provide silent support.
The dieta, which prepares the person for the rite, is as vital as the rite itself. It shows great regard for your own body and spirit as well as for the medication. We want you to cleanse your body at least one to two weeks before your arrival at our ayahuasca workshop in Peru. This entails a bodily purification: giving up pork, alcohol, spicy foods, caffeine, and too much salt and sugar. The mental and spiritual preparation is just as crucial.
We advise abstaining from sexual activity, restricting your exposure to violent or negative news, and centering your energy inward. Meditation, quiet contemplation, and clearly defining your healing goal are all possible during this time. Coming with a clean body and a humble, open heart lets the medicine work with you on a considerably deeper and more profound level.
Totally. For us, the event marks only the start of the healing path. The great insights and lessons from Ayahuasca can vanish like a distant dream without adequate integration. True change comes when you integrate those realizations into the fabric of your everyday life. That is why every one of our Peru packages for ayahuasca retreats comprises a planned integration program.
This entails circles shared the morning following each ceremony, in which you may process your experience in a secure and encouraging group context. We also offer resources and advice on journaling, meditation, and individual contact with our instructors. Our goal is to arm you with the tools you need to continue that healing, not just to provide a strong ayahuasca ritual in Cusco. establishing long-lasting good changes in your life long after you leave the holy mountains of Cusco.
Ayahuasca and San Pedro (Wachuma) are different ancestral medicines. Ayahuasca is usually more introspective and visionary, while San Pedro offers a gentler, heart-centered experience connected to nature. The right choice depends on your intention, personal sensitivity, and previous experience. Read Article
Ayahuasca is a powerful plant medicine and is not suitable for everyone. Certain medical conditions and medications, especially antidepressants, can increase risks. A proper health screening is essential to ensure a safe and responsible ceremony. Read Article
Safety during an ayahuasca retreat depends on experienced shamans, trained facilitators, small group sizes, and clear safety protocols. A well-guided and respectful environment is key to a safe and supportive experience. Read Article
Yes, ayahuasca is legal in Peru and is recognized as part of the country’s ancestral cultural heritage when used in traditional and ceremonial contexts, respecting local laws and indigenous practices. Read Article
Ayahuasca benefits vary from person to person, but many participants report emotional clarity, release of internal blockages, deeper self-awareness, and a stronger spiritual connection when experienced in a guided and intentional setting. Read Article
